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The receptor mediating that effect has not been definitively established
However, joints are also sites where oxidative stress can accumulate, especially after intense physical activity
Never freeze them
(2021) and Mollica et al
Once activated, these caspases cleave gasdermins to liberate the pore-forming N-terminal domains, enabling their targeting of cellular membranes to form large transmembrane pores, which disrupts cellular electrochemical gradient, and leads to water influx and cell swelling (160, 161)
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